The Goldstein Laboratory in the Department of Surgery at Massachusetts General Hospital and MassGeneral Hospital for Children is interested in the development of the enteric nervous system (ENS), a complex neuronal network whose principal function is to maintain normal intestinal motility. Our group of scientists and clinicians seeks to understand the biological mechanisms by which this network arises, and how perturbations to these mechanisms leads to disease. We aim to harness this knowledge to develop novel therapies for children and adults with disorders of the ENS.