Recent Publications


Guyer RA, Mueller JL, and Goldstein AM, Applications of Single-Cell Sequencing Technology to the Enteric Nervous System. Biomolecules 2022 Mar 15;12(3), 452. doi: 10.3390/biom12030452


Gosain A and Goldstein AM, Invited commentary on Ahmad et al.: Routine botulinum toxin injection one month after a Swenson pull-through does not change the incidence of Hirschsprung associated enterocolitis. J Pediatr Surg 2021 Dec 25;S0022-3468(21)00871-X. doi: 10.1016/j.jpedsurg.2021.12.021

Delalande JM et al, TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human. Front Mol Neurosci 2021 Dec 23;14:757646. doi: 10.3389/fnmol.2021.757646.

Nagy N et al, Avian ceca are indispensable for hindgut enteric nervous system development. Development 2021 Nov 15;148(22):dev199825. doi: 10.1242/dev.199825

Pan W, Goldstein AM, and Hotta R, Opportunities for novel diagnostic and cell-based therapies for Hirschsprung disease. J Pediatr Surg 2021 Nov 5;S0022-3468(21)00760-0. doi: 10.1016/j.jpedsurg.2021.10.049

Stavely R et al, Enteric mesenchymal cells support the growth of postnatal enteric neural stem cells. Stem Cells 2021 Sep;39(9):1236-1252. doi: 10.1002/stem.3388

Dora D et al, Evidence of a Myenteric Plexus Barrier and Its Macrophage-Dependent Degradation During Murine Colitis: Implications in Enteric Neuroinflammation. Cell Mol Gastroenterol Hepatol 2021;12(5):1617-1641. doi: 10.1016/j.jcmgh.2021.07.003

Westfal ML et al, Optimal timing for soave primary pull-through in short-segment Hirschsprung disease: A meta-analysis. J Pediatr Surg 2021 Jul 21;S0022-3468(21)00496-6. doi: 10.1016/j.jpedsurg.2021.07.007

Inlender T et al, Homeostasis of mucosal glial cells in human gut is independent of microbiota. Sci Rep 2021 Jun 17;11(1):12796. doi: 10.1038/s41598-021-92384-9

Bhave S et al, Pan-enteric Neuropathy and Dysmotility Are Present in a Mouse Model of Short-Segment Hirschsprung Disease and May Contribute to Post-Pullthrough Morbidity. J Pediatr Surg 2021 Feb;56(2):250-256. doi: 10.1016/j.jpedsurg.2020.04.002


Nagy N et al, RET overactivation leads to concurrent Hirschsprung disease and intestinal ganglioneuromas. Development 2020; Nov 5;147(21):dev190900. doi: 10.1242/dev.190900

Goldstein AM et al, An algorithmic approach to an impactful specific aims page. Surgery 2020 Jul 21;S0039-6060(20)30377-9. doi: 10.1016/j.surg.2020.06.014

Baker C et al, Hypoganglionosis in the Gastric Antrum Causes Delayed Gastric Emptying. Neurogastroenterol Motil 2020 May;32(5):e13766. doi: 10.1111/nmo.13766.


Bhave S and Hotta R, Future Aspect in Taguchi T et al (eds), Hirschsprung’s Disease and the Allied Disorders. Springer 2019. doi: 10.1007/978-981-13-3606-5_31

Bhave S et al, Enteric Neuronal Cell Therapy Reverses Architectural Changes in a Novel Diphtheria Toxin-Mediated Model of Colonic Aganglionosis. Sci Rep 2019 Dec 10;9(1):18756. doi: 10.1038/s41598-019-55128-4.

Steen EH et al, The Pediatric Surgeon-Scientist: Succeeding in Today’s Academic Environment. J Surg Res 2019 Dec;244:502-508. doi: 10.1016/j.jss.2019.06.008.

Veras LV et al, Guidelines for Synoptic Reporting of Surgery and Pathology in Hirschsprung Disease. J Pediatr Surg 2019 Oct;54(10):2017-2023. doi: 10.1016/j.jpedsurg.2019.03.010.

Di Lorenzo C et al, Case 29-2019: A 14-Month-Old Boy With Vomiting. N Engl J Med 2019 Sep 19;381(12):1159-1167. doi: 10.1056/NEJMcpc1904049.

Jaroy EG et al, “Too Much Guts and Not Enough Brains”: (Epi)genetic Mechanisms and Future Therapies of Hirschsprung Disease – A Review. Clin Epigenetics 2019 Sep 13;11(1):135. doi: 10.1186/s13148-019-0718-x.

Saadai P et al, Guidelines for the Management of Postoperative Soiling in Children With Hirschsprung Disease. Pediatr Surg Int 2019 Aug;35(8):829-834. doi: 10.1007/s00383-019-04497-y.

Goldstein AM and Cox NJ, Complex Simplicity and Hirschsprung’s Disease. N Engl J Med 2019 Apr 11;380(15):1478-1479. doi: 10.1056/NEJMe1902827.

Goldstein AM et al, A Roadmap for Aspiring Surgeon-Scientists in Today’s Healthcare Environment. Ann Surg 2019 Jan;269(1):66-72. doi: 10.1097/SLA.0000000000002840.


Dora D et al, Intraganglionic Macrophages: A New Population of Cells in the Enteric Ganglia. J Anat 2018 Oct;233(4):401-410. doi: 10.1111/joa.12863.

Cairo SB et al, Transitions in Care From Pediatric to Adult General Surgery: Evaluating an Unmet Need for Patients With Anorectal Malformation and Hirschsprung Disease. J Pediatr Surg 2018 Aug;53(8):1566-1572. doi: 10.1016/j.jpedsurg.2017.09.021.

Parker KD et al, Microbiome Composition in Both Wild-Type and Disease Model Mice Is Heavily Influenced by Mouse Facility. Front Microbiol 2018 Jul 20;9:1598. doi: 10.3389/fmicb.2018.01598.

Nagy N et al, Collagen 18 and Agrin Are Secreted by Neural Crest Cells to Remodel Their Microenvironment and Regulate Their Migration During Enteric Nervous System Development. Development 2018 May 8;145(9):dev160317. doi: 10.1242/dev.160317.

Cheng LS and Goldstein AM, Surgical Management of Idiopathic Constipation in Pediatric Patients. Clin Colon Rectal Surg 2018 Mar;31(2):89-98. doi: 10.1055/s-0037-1609023.

Nagy N et al, Xenotransplantation of Human Intestine Into Mouse Abdomen or Subcutaneous Tissue: Novel Platforms for the Study of the Human Enteric Nervous System. Neurogastroenterol Motil 2018 Mar;30(3):10.1111/nmo.13212. doi: 10.1111/nmo.13212.

Click here to see all of Dr. Goldstein’s publications in PubMed